Reisa Sperling is a clinical neurologist, a neuroimaging researcher, and a leading force in the movement towards earlier diagnosis and treatment of Alzheimer’s disease. She directs the Center for Alzheimer Research and Treatment at Brigham and Women’s Hospital, the Harvard Aging Brain Study at Massachusetts General Hospital, and is an Associate Professor at Harvard Medical School in Boston. Her pioneering work in multi-modality neuroimaging has served to elucidate the underpinnings of memory changes in aging and early Alzheimer’s disease. She chaired the recent National Institute on Aging-Alzheimer’s Association Workgroup, proposing a research framework to define the “Preclinical Stages” of Alzheimer’s disease, and to facilitate early intervention trials. She is actively working on clinical trials of potential disease-modifying therapies for AD, including secondary prevention trials in asymptomatic individuals with biomarker evidence of preclinical AD.