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This Week at TEDMED: When Trust Becomes the Question

Scientific progress depends on trust, but trust is not guaranteed. This week explores how it’s built, where it breaks, and what happens when the systems behind medicine and research begin to falter.

When Trust Starts to Fracture

In Part 1 of their conversation, Katherine Eban and Jay Walker examine the systems behind scientific truth, including how research is funded, reviewed, and validated. What emerges is a structure under strain, where incentives and opacity shape what becomes accepted as evidence. Trust is not assumed. It is built or weakened by design.

When Evidence Isn’t What It Seems

In Guinea-Bissau, the consequences of those system pressures come into focus. Eban’s reporting reveals how a clinical study involving vulnerable populations raised serious ethical and scientific concerns. Here, questions of oversight and accountability become tangible, shaping real lives, real risks, and real uncertainty about what can be trusted.

The Hidden Risks in the Medicines We Trust

What happens when the systems behind drug approval and manufacturing fail to hold? In her TEDMED Talk, Eban exposes vulnerabilities in the global generic drug supply, where trust is often assumed but not always verified. Seen alongside her reporting and this conversation, the question expands. How do we know when trust has been compromised?

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Theresa Santoro, President and CEO, RVNAhealth

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