Nicole Gaudelli

Nicole Gaudelli is originally from Rochester, NY and received her B.S. degree in Biochemistry from Boston College in May of 2006. She then joined the laboratory of Prof. Craig Townsend at Johns Hopkins University where she studied the biosynthesis of the β-lactam antibiotic Nocardicin. In her doctoral work she elucidated the mechanism through which monobactam antibiotics are biosynthesized. She received her PhD in Chemistry in 2013 and began her postdoctoral fellowship at Harvard University in the laboratory of Prof. David R. Liu. She expanded the capabilities of base-editing technology by creating an adenine base editor (ABE), through 7 rounds of evolution and engineering, which cleanly converts A•T base pairs to G•C base pairs in a programmable manner, with low indel %, and without double-stranded DNA breaks. She recently joined Beam Therapeutics in order to further expand and apply base editing technology to human genetic diseases.