Shai Shen-Orr


New analytical methods introduced by Shai Shen-Orr are providing a clearer understanding of our immune system, how it can be influenced by genetics and environmental factors, and of the potential health implications resulting from these factors. 


Systems Biologist and Data Scientist Shai Shen-Orr is the Co-founder and Chief Scientist of CytoReason and a Professor in the Faculty of Medicine at the Technion—where he directs the laboratory of Systems Immunology and Precision Medicine. In his research, Shai develops new analytical methodologies for grappling with the intricate complexities of the immune system—tools which he has applied to understand how the immune system works in advanced age and to define biomarkers to evaluate immune health. His research has been cited numerous times and has been featured in systems biology textbooks for students. Shai’s research work laid the foundation of CytoReason, a company that uses an artificial intelligence model of the immune-system to make predictions from biological data.


Defective Signaling in the JAK-STAT Pathway Tracks with Chronic Inflammation and Cardiovascular Risk in Aging Humans, 2016.

Activation of the reward system boosts innate and adaptive immunity, 2016. 

Cell type–specific gene expression differences in complex tissues, 2010.