Nicole Gaudelli

What if, instead of treating symptoms of genetic disease, we could correct the cause of the disease?

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About Nicole Gaudelli

Nicole Gaudelli is originally from Rochester, NY and received her B.S. degree in Biochemistry from Boston College in May of 2006. She then joined the laboratory of Prof. Craig Townsend at Johns Hopkins University where she studied the biosynthesis of the β-lactam antibiotic Nocardicin. In her doctoral work she elucidated the mechanism through which monobactam antibiotics are biosynthesized. She received her PhD in Chemistry in 2013 and began her postdoctoral fellowship at Harvard University in the laboratory of Prof. David R. Liu. She expanded the capabilities of base-editing technology by creating an adenine base editor (ABE), through 7 rounds of evolution and engineering, which cleanly converts A•T base pairs to G•C base pairs in a programmable manner, with low indel %, and without double-stranded DNA breaks. She recently joined Beam Therapeutics in order to further expand and apply base editing technology to human genetic diseases.

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About This Idea

What if pathogenic diseases, like sickle cell and Parkinson’s Disease, could be treated before they even appear? Nicole Gaudelli, Senior Scientist & Program Leader at Beam Therapeutics, tells us that state-of-the art gene editing technology can now alter base pairs in genomic DNA. Watch Nicole’s TEDMED 2018 Hive Talk to learn how we can change the future of pathogenic disease, by getting down to the base level.

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More Talks from the Hive

These talks are all a part of special session at TEDMED, called "Audacious" where we invite our innovators to take the stage and share the central idea they are working on, in short 2-minute talks. These talks are creatively grouped by 4 mini-segments, that serves as a creative link between each talk. To find out more visit The Hive page.