Shai Shen-Orr

IN A NUTSHELL

New analytical methods introduced by Shai Shen-Orr are providing a clearer understanding of our immune system, how it can be influenced by genetics and environmental factors, and of the potential health implications resulting from these factors. 

ABOUT SHAI

Systems Biologist and Data Scientist Shai Shen-Orr directs the laboratory of Systems Immunology and Precision Medicine at the Technion-Israel Institute of Technology. Shai’s lab develops new analytical methodologies for grappling with the intricate complexities of the immune system. He also studies how environmental and genetic factors may alter the immune system and how this variability affects health outcomes. Shai and his team have developed a model to understand how the immune system works in advanced age and have defined biomarkers to evaluate immune health. His research has been cited numerous times and has been featured in systems biology textbooks for students.

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Defective Signaling in the JAK-STAT Pathway Tracks with Chronic Inflammation and Cardiovascular Risk in Aging Humans, 2016.

Activation of the reward system boosts innate and adaptive immunity, 2016. 

Cell type–specific gene expression differences in complex tissues, 2010.

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Systems Immunologist